Biomaterials and Biointerfaces for Medical Devices

Mentors:prof. Vladimir Brailovski, Sergey Dubinskiy, Yulia Zhukova, Vadim Sheremetyev
Updated:13 Jul, 2016

Course Summary

The goal of this course is introduction to the proper selection of material to be used as a component of a medical device (prosthesis, implants, transplants, etc.). The course includes: study of biomaterials under a multidisciplinary aspect involving mechanical and physicochemical properties’ analysis in interface with biology and medicine; introduction to materials science; mechanical, physical and chemical properties; the basics of biocompatibility concepts and their importance in the approval of medical devices; biomaterials degradation in service; selection of biomaterials for medical devices; main applications of biomaterials in cardiology, thoracic surgery and orthopedic surgery.

Course Format

Hours of lectureHours of discussionLaboratoryIndependent studyHours total
0240120144

Please note that the time spent on independent study exceeds hours of lecture and discussion.

Course Content

  1. INTRODUCTION IN BIOMATERIALS

    Course review: course outline, objectives and activities. Review of basic concepts in mechanics and materials. Main definitions, classification of biomaterials, functional properties, tissue-biomaterial interaction.

  2. PROPERTIES AND CHARACTERIZATION OF BIOLOGICAL TISSUES

    Constituents of biological materials (inorganic and organic compounds, etc.), structure-property relationships of biological tissues; mineralized tissues, soft, elastic; characterization of biological tissues.

  3. METALLIC BIOMATERIALS

    Structure of metals, classification, main metallic materials, properties, characterization and main applications.

  4. MODIFICATION OF METALLIC MATERIALS: BULK PROPERTIES

    Thermal and thermomechanical treatment and its influence on the microstructure and the structural and functional properties of biomaterials.

  5. MODIFICATION OF METALLIC ALLOYS’ SURFACE PROPERTIES

    Modification of morphology, mechanical, physicochemical and biological properties of metal surfaces.

  6. BIOMATERIAL ANALYSIS TECHNICS: BULK CHARACTERIZATION TECHNIQUES

    Microstructural analysis (X-ray, electron microscopy) and macroscopic (differential scanning calorimetry, mechanical testing, etc.)

  7. BIOMATERIAL ANALYSIS TECHNICS: SURFACE CHARACTERIZATION TECHNIQUES

    Introduction to the surfaces, their properties and surface characterization techniques (wettability, tribological properties, X-ray photoelectron spectroscopy (XPS), Auger spectroscopy, infrared spectroscopy ATR, etc.)

  8. POLYMERIC BIOMATERIALS

    Polymer service properties, polymerization reactions, thermoplastic and thermosetting materials, elastomers, main polymeric biomaterials, biodegradability, examples of application.

  9. CERAMIC AND COMPOSITE BIOMATERIALS

    Structure, composition, production, sintering, concept of inert/bioactive biomaterials, bioglasses, main applications

  10. MECHANICAL DESIGN OF MEDICAL DEVICES

    Requirements, static and dynamic mechanical properties, lifetime, safety factors, material selection principles.

  11. BIOCOMPATIBILITY

    Introduction to systems and stages of tissue healing, infection, major adverse events (cytotoxicity, carcinogenicity, mutagenicity ...) main biocompatibility testing, ISO 10993 standards.

  12. BIOMATERIALS’ DEGRADATION IN SERVICE

    Corrosion, wear, erosion, aging, dissolution, oxidation, degradation and their consequences.

  13. STANDARDS AND CONTROL

    National standards and regulations for medical devices: Canada, USA, Europe, guidelines for the design, quality control and application of biomedical devices

  14. ISSUES AND CHALLENGES

    Sterilization and other issues related to biomaterials: practical examples.

Textbooks

Primary textbooks:

  1. J.S. Temenoff, A.G. Mikos, Biomaterials: The Intersection of Biology and Materials Science, Prentice Hall, 2008.
  2. Biomaterials: An introduction. Park J, Lakes RS (Eds) 3rd edition. Springer, 2007.
  3. Design of biomedical devices and systems. King PH, Fries RC (Eds) Marcel Dekker, 2003.
  4. Biomaterials Science (An Introduction to Materials in Medecine), Eds. B.D. Ratner, A.S. Hoffman, F.J. Schoen and J.E. Lemons, Elsevier Academic Press, 2nd edition, 2004
  5. An Introduction to Tissue Biomaterial Interactions. Eds. K.C. Dee, D.A. Puleo, R. Bizios, WileyLiss, 2003.

Databases:

Grading

Class participation10%
Homework assignments30%
Midterm exam30%
Final exam30%