|Mentors:||prof. Vladimir Brailovski, Sergey Dubinskiy, Yulia Zhukova, Vadim Sheremetyev|
|Updated:||13 Jul, 2016|
The goal of this course is introduction to the proper selection of material to be used as a component of a medical device (prosthesis, implants, transplants, etc.). The course includes: study of biomaterials under a multidisciplinary aspect involving mechanical and physicochemical properties’ analysis in interface with biology and medicine; introduction to materials science; mechanical, physical and chemical properties; the basics of biocompatibility concepts and their importance in the approval of medical devices; biomaterials degradation in service; selection of biomaterials for medical devices; main applications of biomaterials in cardiology, thoracic surgery and orthopedic surgery.
|Hours of lecture||Hours of discussion||Laboratory||Independent study||Hours total|
Please note that the time spent on independent study exceeds hours of lecture and discussion.
INTRODUCTION IN BIOMATERIALS
Course review: course outline, objectives and activities. Review of basic concepts in mechanics and materials. Main definitions, classification of biomaterials, functional properties, tissue-biomaterial interaction.
PROPERTIES AND CHARACTERIZATION OF BIOLOGICAL TISSUES
Constituents of biological materials (inorganic and organic compounds, etc.), structure-property relationships of biological tissues; mineralized tissues, soft, elastic; characterization of biological tissues.
Structure of metals, classification, main metallic materials, properties, characterization and main applications.
MODIFICATION OF METALLIC MATERIALS: BULK PROPERTIES
Thermal and thermomechanical treatment and its influence on the microstructure and the structural and functional properties of biomaterials.
MODIFICATION OF METALLIC ALLOYS’ SURFACE PROPERTIES
Modification of morphology, mechanical, physicochemical and biological properties of metal surfaces.
BIOMATERIAL ANALYSIS TECHNICS: BULK CHARACTERIZATION TECHNIQUES
(X-ray,electron microscopy) and macroscopic (differential scanning calorimetry, mechanical testing, etc.)
BIOMATERIAL ANALYSIS TECHNICS: SURFACE CHARACTERIZATION TECHNIQUES
Introduction to the surfaces, their properties and surface characterization techniques (wettability, tribological properties,
X-rayphotoelectron spectroscopy (XPS), Auger spectroscopy, infrared spectroscopy ATR, etc.)
Polymer service properties, polymerization reactions, thermoplastic and thermosetting materials, elastomers, main polymeric biomaterials, biodegradability, examples of application.
CERAMIC AND COMPOSITE BIOMATERIALS
Structure, composition, production, sintering, concept of inert/bioactive biomaterials, bioglasses, main applications
MECHANICAL DESIGN OF MEDICAL DEVICES
Requirements, static and dynamic mechanical properties, lifetime, safety factors, material selection principles.
Introduction to systems and stages of tissue healing, infection, major adverse events (cytotoxicity, carcinogenicity, mutagenicity ...) main biocompatibility testing, ISO 10993 standards.
BIOMATERIALS’ DEGRADATION IN SERVICE
Corrosion, wear, erosion, aging, dissolution, oxidation, degradation and their consequences.
STANDARDS AND CONTROL
National standards and regulations for medical devices: Canada, USA, Europe, guidelines for the design, quality control and application of biomedical devices
ISSUES AND CHALLENGES
Sterilization and other issues related to biomaterials: practical examples.
- J.S. Temenoff, A.G. Mikos, Biomaterials: The Intersection of Biology and Materials Science, Prentice Hall, 2008.
- Biomaterials: An introduction. Park J, Lakes RS (Eds) 3rd edition. Springer, 2007.
- Design of biomedical devices and systems. King PH, Fries RC (Eds) Marcel Dekker, 2003.
- Biomaterials Science (An Introduction to Materials in Medecine), Eds. B.D. Ratner, A.S. Hoffman, F.J. Schoen and J.E. Lemons, Elsevier Academic Press, 2nd edition, 2004
- An Introduction to Tissue Biomaterial Interactions. Eds. K.C. Dee, D.A. Puleo, R. Bizios, WileyLiss, 2003.
- ASM handbook online https://products.asminternational.org/hbk/index.jsp
- Material Property Data online https://www.matweb.com/index.aspx
- Materials for Medical Devices Database: https://asmcommunity.asminternational.org/portal/site/asm/
- Pubmed https://www.ncbi.nlm.nih.gov/sites/entrez