Abstract: the objective of current study was to design a bioactive and mechanically stable ceramic/polymer cement for repairing bone defects. Solvent casting method was utilized to prepare porous diopside/PMMA scaffolds. The characteristic functional groups associated with diopside and PMMA in the composites were confirmed by FT-IR spectroscopy. Scanning electron microscopy revealed that the surface of composites were covered with small non-uniform pores having dimensions below 4 μm. It was found that the porosity of the composites can be altered by varying the content of filler (diopside) in the composites. The biomineralization ability and mechanical strength of PMMA was enhanced by fabricating it as a composite with diopside. The presence of apatite peaks on the surface of diopside/PMMA composites was observed after four weeks of immersion. The mechanical strength of diopside/PMMA composites was found to match with cancellous bone. Hence, the compositional ratio and constituents played a key role in determining the activity of the composites. Bioactive silicates can be used as a fillers in biomedical polymers for imparting ductility to ceramics for achieving advanced functionalities.